Zyderm and Zyplast Collagen Replacement Therapy have been proven safe and effective for over 15 years. Zyderm and Zyplast collagen implants have been used in over 1.5 million treatments worldwide. They are the only injectable collagen products for use in facial aesthetics to undergo rigorous studies in 5,000 patients and the only injectable collagen products to be subjected to the strict device approval process of the Food and Drug administration.

What is Collagen?
Collagen, a naturally occurring fibrous protein found in both humans and animals, provides structural support for bones, skin, tendons, ligaments, and blood vessels and is the most abundant protein in the body.

What is Collagen Replacement Therapy®?
Zyderm and Zyplast collagen implants, also known as Collagen Replacement Therapy, are safe, non-surgical treatments in which highly purified bovine dermal collagen is injected into the skin to replenish the skin's natural collagen.

Where Does Bovine Collagen Come From?
Zyderm and Zyplast collagen implants are composed of highly purified bovine dermal tissue. This material is obtained from the hides of steers within a closed herd.

What is a Closed Herd?
A closed herd is defined as one in which:

• There has been no case of BSE
• There has been no feeding of mammalian-derived protein (animal by-products)
• There is a fully documented breeding history
• There has been fully documented veterinary monitoring
• Each animal is monitored and traceable, and
• Genetic material has been introduced only from herds with the same BSE-free status.

How was Injectable Collagen Developed?
In the 1970's, a group of physicians and scientists at Stanford University were researching alternatives to skin grafts, and developed the concept of purifying bovine dermal collagen so thoroughly that it could be used to replace lost skin tissue. This early research led to the development of Zyderm and Zyplast collagen implants (injectable collagen) by McGhan Medical Corporation (formerly by Collagen Aesthetics, Inc.). Zyderm and Zyplast collagen implants are FDA approved.

What would one choose Collagen Replacement Therapy®?
When a person smiles, frowns, or squints; stress is placed on the collagen in the skin, wearing it down and resulting in the formation of facial lines and wrinkles. Zyderm and Zyplast collagen injections can improve the appearance of the skin by reducing lines and wrinkles.

How long have people been using bovine-bases collagen?
Zyderm and Zyplast bovine-based collagen has been the preferred source for injectable collagen since 1981. Over 1.5 million patients have been treated with Zyderm and Zyplast collagen implants worldwide.

Has bovine-based collagen been approved by the FDA?
YES. Zyderm and Zyplast collagen implants made by McGhan Medical, are FDA-approved collagens for facial injection.

What is Bovine Spongiform Encephalopathy (BSE)- “Mad Cow Disease?”
BSE is a chronic, degenerative disease affecting the central nervous system of cattle. Scientists speculate that cattle contract BSE from eating BSE-infected mammalian-derived protein (food processed from other animals.) BSE is isolated to only the brain and central nervous system tissues of cattle. BSE is not found in dermal tissue.

Have there been any reported cases of BSE in the US ?
No. The United States Department of Agriculture (USDA) certifies that BSE has not been detected in U.S. cattle. BSE is not known to exist in the United States .

Has there been a case of BSE in the closed herd from which Zyderm and Zyplast are sourced?
There has been no case of BSE or any other herd-threatening disease in the closed cattle herd used to source Zyderm and Zyplast.

How do we know McGhan Medical's bovine-based collagen facial injections are safe and free of contamination?
McGhan Medical manufactures a highly purified form of bovine collagen, derived from a USDA-certified and carefully monitored closed herd of cattle in California .

What steps are taken to ensure the safety of Zyderm and Zyplast collagen products?
To ensure that only the safest and highest quality product is produced, the entire process is controlled, sourced from a closed herd, processed and manufactured in a state-of-the-art facility, to produce Zyderm and Zyplast collagen implants.

Where can I get more information on BSE?
The following website resources may help y ou find more information regarding BSE:

• U.S. Food and Drug Administration at www.fda.gov
• U.S. Department of Health and Human Services at www.hhs.gov
• U.S. Department of Agriculture at www.usda.gov
• Center for Disease Control and Prevention at www.cdc.gov

Please consult Dr. Rothchild for any further questions you may have regarding Collagen Replacement Therapy®: