Collagen
Replacement Therapy
Zyderm
and Zyplast Collagen Replacement Therapy have been proven
safe and effective for over 15 years. Zyderm and Zyplast
collagen implants have been used in over 1.5 million treatments
worldwide. They are the only injectable collagen products
for use in facial aesthetics to undergo rigorous studies
in 5,000 patients and the only injectable collagen products
to be subjected to the strict device approval process of
the Food and Drug administration.
What is Collagen?
Collagen, a naturally occurring
fibrous protein found in both humans and animals, provides
structural support for bones, skin, tendons, ligaments,
and blood vessels and is the most abundant protein in the
body.
What
is Collagen Replacement Therapy®?
Zyderm
and Zyplast collagen implants, also known as Collagen Replacement
Therapy, are safe, non-surgical treatments in which highly
purified bovine dermal collagen is injected into the skin
to replenish the skin's natural collagen.
Where Does Bovine Collagen Come From?
Zyderm and
Zyplast collagen implants are composed of highly purified
bovine dermal tissue. This material is obtained from the
hides of steers within a closed herd.
What is a Closed Herd?
A closed herd is defined
as one in which:
- There has been no case of BSE
- There has been no feeding of mammalian-derived protein
(animal by-products)
- There is a fully documented breeding history
- There has been fully documented veterinary monitoring
- Each animal is monitored and traceable, and
- Genetic material has been introduced only from herds
with the same BSE-free status.
How was Injectable Collagen Developed?
In the 1970's,
a group of physicians and scientists at Stanford University
were researching alternatives to skin grafts, and developed
the concept of purifying bovine dermal collagen so thoroughly
that it could be used to replace lost skin tissue. This
early research led to the development of Zyderm and Zyplast
collagen implants (injectable collagen) by McGhan Medical
Corporation (formerly by Collagen Aesthetics, Inc.). Zyderm
and Zyplast collagen implants are FDA approved.
What
would one choose Collagen Replacement Therapy®?
When
a person smiles, frowns, or squints; stress is placed on
the collagen in the skin, wearing it down and resulting
in the formation of facial lines and wrinkles. Zyderm and
Zyplast collagen injections can improve the appearance
of the skin by reducing lines and wrinkles.
How long have people been using bovine-bases collagen?
Zyderm
and Zyplast bovine-based collagen has been the preferred
source for injectable collagen since 1981. Over 1.5 million
patients have been treated with Zyderm and Zyplast collagen
implants worldwide.
Has bovine-based collagen been approved by the FDA?
YES.
Zyderm and Zyplast collagen implants made by McGhan Medical,
are FDA-approved collagens for facial injection.
What
is Bovine Spongiform Encephalopathy (BSE)- “Mad
Cow Disease?”
BSE is a chronic, degenerative disease
affecting the central nervous system of cattle. Scientists
speculate that cattle contract BSE from eating BSE-infected
mammalian-derived protein (food processed from other
animals.) BSE is isolated to only the brain and central
nervous system tissues of cattle. BSE is not found in
dermal tissue.
Have there been any reported cases of BSE in the US
?
No. The United States Department of Agriculture
(USDA) certifies that BSE has not been detected in U.S.
cattle. BSE is not known to exist in the United States
.
Has there been a case of BSE in the closed herd from
which Zyderm and Zyplast are sourced?
There has been
no case of BSE or any other herd-threatening disease
in the closed cattle herd used to source Zyderm and Zyplast.
How do we know McGhan Medical's bovine-based collagen
facial injections are safe and free of contamination?
McGhan
Medical manufactures a highly purified form of bovine
collagen, derived from a USDA-certified and carefully
monitored closed herd of cattle in California .
What steps are taken to ensure the safety of Zyderm
and Zyplast collagen products?
To ensure that only
the safest and highest quality product is produced, the
entire process is controlled, sourced from a closed herd,
processed and manufactured in a state-of-the-art facility,
to produce Zyderm and Zyplast collagen implants.
Where can I get more information on BSE?
The following
website resources may help you find more information regarding
BSE:
Please
consult Dr. Rothchild for any further questions you may
have regarding Collagen Replacement Therapy®:
Rothchild Eye institute
16244 S. Military Trail Suite 690
Delray Beach, FL 33484
Phone - (561) 495-2811
Fax - (561) 495-9538
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